But worry not, that doesn't mean Clooney has totally stopped pulling jokes—he's just finding more adult ways of incorporating them into his art.
While making their newest film, Damon says that the Oscar winner insisted on finding the smallest bike for a scene, making the Jason Bourne actor ride around with his knees "out to the side like wings."
Despite their reputation for being big jokesters with one another, the longtime friends have each other's backs at the end of the day.
During the sit-down, Damon, who has three children and a stepdaughter with wife Luciana Barroso, told Scoles he would watch Clooney's twins Alexander and Ella—but would need the help of his wife.
For him, twins are on a "whole other level" and therefore not in his realm of experience, but that he has "had a lot of babies so I can do one a time."